Southwest Cajun Dry Rub

If you’re looking to add a serious kick to your grilling game or spice up your everyday meals, this Southwest Cajun Dry Rub is the seasoning you’ve been missing. It brings together bold Cajun flavors with a Southwest twist—smoky, spicy, and savory, all in one. Perfect for grilling, roasting, or even just tossing on some veggies!

Small white bowl of Southwest cajun dry rub in a silver spoon in the bowl.

This Southwest Cajun dry rub was inspired by the vibrant mix of flavors found in Cajun cooking, with a Southwest twist that kicks things up a notch. Cajun flavors are unique, originating from a blend of cultures in the South that mix French herbs with chiles and warm spices from the Caribbean and Central America.

Inspired by the fusion of cultures, I decided to press the flavors towards the Southwest, focusing on savory herbs and local chiles. We’re talking smoky paprika, earthy chipotle, and a hit of Mexican oregano layered with classic Cajun elements like cayenne, thyme, and allspice. The result? A rub that’s great for grilling or smoking meats, but it doesn’t stop there—try it on smoked turkey breast, Cajun chicken wings, Cajun pork ribs, roasted veggies, beans, or even scrambled eggs!

Why This Works

  • Bold & balanced: The mix of herbs and chiles delivers heat without being overwhelming!
  • No sugar: Since this Cajun dry rub recipe has no sugar, it is perfect for grilling or smoking without worrying about burning the rub.
  • Customizable: Skip the salt for a low-sodium version or adjust the cayenne to dial up or down the heat.
Spoonful of Southwest cajun dry rub next to a bowl of more dry rub.

Key Ingredients

  • Salt & pepper — I recommend kosher coarse salt and freshly cracked black pepper.
  • Smoked paprika — For a hint of smoky flavor. If you don’t have it, you can just regular paprika instead.
  • Cayenne pepper — Gives this rub its signature heat. Add more if you like it spicy!
  • Mexican oregano — Stronger than your regular oregano, it’s slightly citrusy and pairs well with the smoky and spicy elements in this dry rub.
  • Granulated garlic — An essential ingredient to add a savory depth!
  • Chipotle powder — Smoky, spicy, and just a little bit earthy.
  • Dried parsley — For a little bit of freshness!
  • Dried thyme — Thyme lends those Cajun vibes.
  • Ground allspice — Brings a warming spice element that’s also key to a Cajun-inspired rub.

Substitutions or Variations for Flavor

  • Chipotle powder: Can’t find it? Swap in smoked chili powder or even ground ancho chile for a slightly milder heat.
  • Mexican oregano: Regular oregano will work in a pinch, but the flavor won’t be quite as bold.
  • More heat: Throw in extra cayenne or even some red pepper flakes if you want to really crank up the spice.
  • Need a Salt Free Cajun Seasoning? Use this recipe and skip the salt. It’s packed with plenty of flavors from the chiles, herbs, and spices. You can use it to season soups, beans, rice, vegetables, and anything else that would require little to no added salt.

How to Make Southwest Cajun Dry Rub

  1. Combine ingredients. Mix the ingredients in a small bowl. Taste and adjust as needed.
  2. Store. Store in an airtight container. This dry rub recipe will stay the freshest for about a month.
Small bowl of Southwest cajun seasoning with a spoon in it.

Top Tips

  • Adjust to taste. Everyone’s spice tolerance is different, so taste as you go. You can always add more heat but you can’t take it away! Luckily, Southwest Cajun dry rub is versatile so you can adjust it to your own liking.
  • To store, keep your rub in an airtight container in a cool, dry place, and it’ll stay fresh for about a month.
  • For the best results, apply this BBQ rub generously and let it sit on the meat for at least 30 minutes before cooking to let those flavors really sink in!
Southwest cajun dry rub in a bowl with pieces of meat in the background that have been coated in the dry rub.

How to Use Southwest Cajun Dry Rub

This Cajun rub can be used for grilling or smoking, as it has no sugar (similar to Sedona Sand All-Purpose Seasoning). So you can try it on any grilled or smoked meats like reverse seared tri-tip steaks or smoked chicken drumsticks!

Or, you can use this dry rub with any of my Cajun-inspired recipes like my Cajun chicken wings, spicy Cajun pork ribs, or Cajun steak and shrimp etouffee. It will really take the spicy, Cajun flavors up a notch!

It’s also a great seasoning to sprinkle on roasted veggies, homemade beans, or eggs as well. It would go amazingly sprinkled into blackened corn, Tennessee onions, Southwest creamed corn, or stirred into Southern macaroni salad!

Elote creamed corn in a bowl with blue corn chips

Frequently Asked Questions

Can I make the dry rub ahead of time?

Absolutely! Make a quick batch and store it in an airtight container for up to a month.

Is this Southwest Cajun dry rub too spicy for kids?

The cayenne here does add a significant amount of heat, but you can adjust the amount or leave it out entirely if you’re worried about it being too spicy!

Can I use Cajun dry rub to season fish?

Definitely! This rub would be great on grilled fish or shrimp—just use a lighter hand when applying so you don’t overpower the fish’s natural flavor.

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Southwest cajun dry rub seasoning in a white ramekin with a silver spoon.

Southwest Cajun Dry Rub

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If you’re looking to add a serious kick to your grilling game or spice up your everyday meals, this Southwest Cajun Dry Rub is the seasoning you’ve been missing. It brings together bold Cajun flavors with a Southwest twist—smoky, spicy, and savory, all in one. Perfect for grilling, roasting, or even just tossing on some veggies!

  • Total Time: 5 minutes
  • Yield: About 3/4 cup

Ingredients

Scale
  • 2 tablespoons black pepper
  • 2 tablespoons kosher salt
  • 2 tablespoons smoked paprika
  • 1 tablespoons cayenne
  • 2 tablespoons Mexican oregano
  • 2 teaspoons granulated garlic
  • 1 teaspoon chipotle powder
  • 1 teaspoon dried parsley
  • 1 teaspoon dried thyme
  • ½ teaspoon ground allspice

Instructions

  1. Mix the ingredients in a small bowl. Taste and adjust as needed.
  2. Store in an airtight container. This dry rub recipe will stay the freshest for about a month.

Notes

  • Are you seeking a Salt Free Cajun Seasoning? Use this recipe and skip the salt. It’s packed with plenty of flavors from the chiles, herbs, and spices. You can use it to season soups, beans, rice, vegetables, and anything else that would require little to no added salt.
  • Author: Brad Prose
  • Prep Time: 5 minutes
  • Category: Rubs & Seasonings
  • Method: Mixing
  • Cuisine: BBQ Rub, Seasoning, Spice Blend

Nutrition

  • Serving Size: 1 teaspoon
  • Calories: 4
  • Sugar: 0.1 g
  • Sodium: 215.4 mg
  • Fat: 0.1 g
  • Carbohydrates: 0.9 g
  • Protein: 0.2 g
  • Cholesterol: 0 mg
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